栾明明 博士，硕士生导师
联系方式
邮箱：luanmm@qlu.edu.cn
办公室：食工楼C517
学习及工作经历
2018.12-至今 56net亚洲必嬴 必赢56net在线登录
2013.09-2018.12 山东师范大学 化学化工与材料科学学院 分析化学 博士
2008.09-2013.07 烟台大学文经学院 食品与生物工程系 讲师
2006.04-2008.07 常熟理工学院 化学与材料工程系 讲师
2003.09-2006.04 浙江大学 化学系 分析化学 硕士
1999.09-2003.07 烟台大学 化学生物理工学院 应用化学 学士
研究领域
1. 纳米荧光探针的设计构建及其在生物成像中的应用
2. 早期肿瘤标志物和抗癌药物疗效的可视化诊断、评估
主持和参与科研项目
1. 国家自然科学基金青年项目，高灵敏纳米荧光探针用于动态可视化监测microRNA调控癌细胞凋亡及其在药效评估的应用（项目号21904074, 2020.01.01-2022.12.31, 25万元, 结题，主持）
2. 国家自然科学基金面上项目，表面与针尖增强拉曼光谱的高精度量子化学计算与人工智能预测 （项目号22073053, 2021.01.01-2024.12.31, 63万元, 在研，参与）
3. 国家自然科学基金面上项目，纳米载体材料对细胞的安全性评估：比率荧光纳米探针实时检测成像活性氧水平的变化, （项目号21775094, 2018.01.01-2021.12.31, 64万元, 结题，参与）
4. 国家自然科学基金重点项目，亚细胞结构水平上活性小分子协同调控细胞功能的荧光成像研究（项目号21535004，2016.01.01-2020.12.01，300.00万元，结题，参与）
5. 国家重大科研仪器研制项目，单分子检测系统及其关键技术研究（项目号21527811，2016.01.01-2020.12.01，548.00万元，结题，参与）
发表论文
15. Mingyao Ren, Zhe Chen, Chuandong Ge, Wei Hu, Jing Xu, Limin Yang, Mingming Luan* and Nianxing Wang* Visualizing MiRNA Regulation of Apoptosis for Investigating the Feasibility of MiRNA-Targeted Therapy Using a Fluorescent Nanoprobe. Pharmaceutics.2022, 14, 1349. 2022-06-25
14. Mingyao Ren†, Zhe Chen†, Chuandong Ge, Wei Hu, Nianxing Wang, Limin Yang, Mingming Luan* and Jing Xu* Simultaneous Visualization of MiRNA-221 and Caspase-3 in Cancer Cells for Investigating the Feasibility of MiRNA-Targeted Therapy with a Dual-color Fluorescent Nanosensor. Biosensors.2022, 12, 444. 2022-06-23
13. Bo Liu, Ping Zhou, Kaiye Wang, Shaohua Gong, Mingming Luan, Na Li*, and Bo Tang*. Avoiding False Positive Signals: A Powerful and Reliable Au−Se Dual-Color Probe. ACS Sens.2021, 6(5), 1949–1955.
12. Ping Zhou,a Bo Liu,aMingming Luan,b Na Li *a and Bo Tang *a A fluorescence nanoprobe for detecting the effect of different oxygen and nutrient conditions on breast cancer cells migration and invasion. Biomater. Sci., 2021, 9(12), 4428-4432.
11. Chunhong Gao a,#, Zhen Zhang a,#, Shu Xing a, Mingming Luana, Tingting Gai a, Zhaosheng Hou b, Tianduo Li a, Jing Xu a,* Self-assembled gelatin monolayer with coordinating regulation the composition, charge and wettability on the titanium surface
Surfaces and Interfaces， Volume 25, August 2021, 101281
10. Xiaonan Gao 1, Jia Li 1, Mingming Luan, Yanhua Li, Wei Pan, Na Li *, Bo Tang **. Real-time in situ monitoring of signal molecules’ evolution in apoptotic pathway via Au–Se bond constructed nanoprobe. Biosens. Bioelectron. 2020, 147, 111755.
9. Mingming Luan, Wei Pan, Na Li*, and Bo Tang*, Real-Time in Situ Investigation of Upstream and Downstream Relationship between uPA and MMP-9 in MCF-7 and PANC-1 cells via Au-Se-Bond-Based Nanoprobe. Chem. Commun., 2019, 55, 5817-5820.
8. Mingming Luan, Jinjie Chang, Wei Pan, Yuanyuan Chen, Na Li* and Bo Tang*, Simultaneous Fluorescence Visualization of Epithelial–Mesenchymal Transition and Apoptosis Processes in Tumor Cells for Evaluating the Impact of Epithelial–Mesenchymal Transition on Drug Efficacy. Anal. Chem., 2018, 90, 10951-10957.
7. Mingming Luan, Longhai Yu, Yanhua Li, Wei Pan, Xiaonan Gao, Xiuyan Wan, Na Li* and Bo Tang*, Visualizing Breast Cancer Cell Proliferation and Invasion for Assessing Drug Efficacy with a Fluorescent Nanoprobe. Anal. Chem., 2017, 89, 10601-10607.
6. Mingming Luan, Na Li, Wei Pan, Limin Yang, Zhengze Yu and Bo Tang*, Simultaneous detection of multiple targets involved in the PI3K/AKT pathway for investigating cellular migration and invasion with a multicolor fluorescent nanoprobe. Chem. Commun., 2017, 53, 356-359.ESI高被引
5.栾明明，邬建敏，叶庆富, 多次循环离子交换色谱纯化Cry1Ab 蛋白及其肽质量谱图的分析. 浙江大学学报, 2007, 529-532.
4. Jianmin Wu, Mingming Luan, Jiayin Zhao. Trypsin immobilization by direct adsorption on metal ion chelated macroporous chitosan-silica gel beads. International Journal of Biological Macromolecules. 2006, 39, 185–191.
3. 栾明明，邬建敏，溶胶凝胶膜包埋的胰蛋白酶用于高通量蛋白质肽谱分析.分析化学, 2006, 34, 1707-1710.
2. Mingming Luan, Fengna Xi, Jianmin Wu. New metal chelate affinity adsorbent for trypsin immobilization. Abstract Book of International Symposium on Biocatalysis and Bioprocess Engineering. 2005, 126-127.
1. Fengna Xi, Jianmin Wu, Mingming Luan. Silica-supported macroporous chitosanbead for affinity purification of trypsin inhibitor. Chinese Chemical Letters. 2005, 16.
奖励和荣誉：
山东省高等学校科学技术奖一等奖，第四位，2019.12.23
主讲课程：
工程化学、无机化学、分析化学、仪器分析、环境监测等课程
